Adverse Drug Reactions-

By Wally Kassebaum  |  Submitted On March 07, 2015.

 Over 100,000 deaths occur each year due to adverse drug reactions or ADRs. That's equivalent to a Boeing 737 crashing every day for a year. Do you want to be on one of those planes? Did you know that with the introduction of Pharmacogenetic testing (PGT), a simple inside the mouth cheek swab, can prevent most of these needless deaths?

A properly administered PGT panel is designed to help physicians determine a patient's ability to metabolize pain medications.

PGT detects single nucleotide polymorphism (SNPs) in five cytochrome P450 (CYPs) genes whose enzymes, predominantly expressed in the liver, are responsible for metabolizing many commonly prescribed medications. Lab results are expressed as poor (PM), intermediate (IM), extensive (EM), and ultrarapid (UM) metabolizers with varying degree of drug metabolizing capability. Physicians can adjust the medication accordingly to achieve the optimal treatment plan for the patient.

The panels can help a physician decide the best course of treatment and deliver

personalized medicine in order to achieve the best results. It can also help reduce adverse drug reactions, avoid drug-drug interactions, prevent drug overdose episodes, save precious individual drug trial time, and reduce medical costs.

A PGT is administered using buccal swabs or whole blood specimens. It's important to use a lab that both FDA and laboratory-developed methods are CLIA compliant.

Pain Management Panel-

Here is an example of the genes that are reactive to certain drugs.:

CYP2C9-

meloxicam, celecoxib, ibuprofen, naproxen, acetaminophen, lumiracoxib

CYP2C19-

methadone, meperidine, ibuprofen

CYP2DC-

codeine, hydrocodone, oxycodone, tramadol, duloxetine

CYP3A4, CYP3A5-

buprenorphine, fentanyl, methadone, tramadol, meperidine, meloxicam, celecoxib, acetaminophen

CYP METABOLIZER TYPE AND ACTION

Example of Analgesic Effects "before" metabolism using acetaminophen, buprenorphine, fentanyl, meperidine, methadone, meloxicam, celecobix, duloxetine, ibuprofen, or naproxen:

Metabolizer Type PM

• Highly Reduced Metabolism
• Active Drug Accumulates
• Decreased Dosage Or Use Alternative Drug

Metabolizer Type IM

• Reduced Metabolism
• Active Drug Accumulates
• Decrease Dosage or Use Alternate Drug

Metabolizer Type EM

• Normal
• No Change Needed

Metabolizer Type UM

• Enhanced Metabolism
• Rapid Activation And Deactivation
• Increase Dosage Or Use Alternate Drug

Example of Analgesic Effects "after" metabolism using codeine, hydrocodone, oxycodone, tramadol:

Metabolizer Type PM

• Highly Reduced Metabolism
• Pro Drug Accumulates
• Increase Dosage Or Use Alternate Drug

Metabolizer Type IM

• Reduced Metabolism
• Pro Drug Accumulates
• Increase Dosage or Use Alternate Drug

Metabolizer Type EM

• Normal
• No Change Needed

Metabolizer Type UM

• Enhanced Metabolism
• Active Drug Accumulates
• Decrease Dosage Or Use Alternate Drug

Candidates For PGT Pain Panel Include:

• Abnormally high or low metabolite to substrate ratio in urine drug screening
• Multiple organ system issues
• Multiple medications
• Serious adverse drug reactions
• Sequential ineffective individual drug trials

You can improve patient outcomes significantly and effectively with the use of PGT testing to significantly reduce the ADRs in your community.

Insurance companies and Medicare now cover these tests based on normal protocols of necessity. Health Practitioners can earn a substantial income through this revolutionary testing with results coming from a very prestigious US Lab. To get more information for your practice click:HERE

Representatives who offer Pharmacogenetic Testing to health care practitioners, clinics or hospitals will earn substantial revenues for each test. Get started today and become a rep who makes more than the average doctor. More Information